Palladium-Catalyzed Cross-Coupling of Alkynylzincs with Allylic Electrophiles: An Efficient and Selective Synthesis of Stereo- and Regio-Defined 1,4-Enynes

Clean and high-yielding cross-coupling of alkynylzincs with allylic chlorides, bromides, or acetates exhibiting 98% regio- and stereoselectivity can be achieved by using 1 mol% of Pd(DPEphos)Cl2 and either 1:1 THF-DMF or pure DMF. This reaction provides a satisfactory route to 1,4-enynes via Pd-catalyzed alkynyl-allyl coupling.