Title of article :
Synthesis, characterization and theoretical evaluations of HMDS promoted chemoselective O-alkylation of uracils
Author/Authors :
Mehdi Bakavoli، نويسنده , , Hossein Eshghi، نويسنده , , Ali Shiri، نويسنده , , Toktam Afrough، نويسنده , , Javad Tajabadi، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
The sodium salts of the conjugated bases of uracils undergo highly chemoselective O4-monoalkylation when treated with various alkyl halides in dry DMF, while the use of methyl iodide results in N1+N3-dimethylation. Theoretical evaluations of the chemo- and regioselectivity along with X-ray crystallographic data are presented.
Keywords :
6-Methyl uracil , HMDS , O-alkylation , GIAO 13C NMR
Journal title :
Tetrahedron
Journal title :
Tetrahedron
