Title of article
Synthesis of indoles with a polyfluorinated benzene ring
Author/Authors
Larisa V. Politanskaya، نويسنده , , Igor P. Chuikov، نويسنده , , Vitalij D. Shteingarts، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
10
From page
8477
To page
8486
Abstract
A two-step sequence consisting of a Sonogashira coupling of polyfluorinated 2-iodoanilines with terminal alkynes, followed by a KOH promoted cyclization of the 2-alkynylanilines thus formed, has been developed as a one-pot synthesis of 2-R-indoles (R=n-Bu, Ph, CH2OTHP→CH2OH, C(CH3)2OH→H) containing a polyfluorinated benzene moiety.
Keywords
One-pot synthesis , Cyclization of polyfluorinated ortho-alkynylanilines , Coupling reactions , Polyfluorinated indoles
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1106283
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