Title of article
Versatile Synthesis of 1,1-Diaryl-1-alkenes Using Vinylboronate Ester as a Platform
Author/Authors
Yoshida، Jun-ichi نويسنده , , Itami، Kenichiro نويسنده , , Tonogaki، Keisuke نويسنده , , Soga، Kazuya نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-1801
From page
1802
To page
0
Abstract
A sequence of double Mizoroki-Heck reaction of vinylboronate pinacol ester with aryl halides followed by Suzuki-Miyaura coupling of thus-generated (beta),(beta)-diarylvinylboronate esters with alkyl halides produces pharmaceutically important 1,1-diaryl-1-alkenes very efficiently. In the Pd-catalyzed Suzuki-Miyaura coupling step, the use of bulky electron-rich ligands such as P(t-Bu)2Me and PCy2(t-Bu) were found to be very effective.
Keywords
vinylboronate ester , Suzuki-Miyaura coupling , Mizoroki-Heck reaction , alkyl halides , palladium catalyst
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110634
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