Title of article :
Highly Diastereoselective Desymmetrisation of Cyclic meso-Anhydrides and Derivatisation to Mono-Protected 1,4-Diols
Author/Authors :
Matsuoka، Masato نويسنده , , Ley، Steven V. نويسنده , , Evans، Amanda C. نويسنده , , Longbottom، Deborah A. نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A new and efficient desymmetrisation of bi- and tricyclic meso-anhydrides is described, providing good yields and diastereoselectivities in all cases (routinely >95% de). Derivatisation of the chiral compounds synthesised is then demonstrated by their conversion into mono-protected 1,4-diols.
Keywords :
anhydride , chiral auxiliary , diastereoselectivity , desymmetrisation , Stereoselective synthesis
