Regio- and Diastereoselective Synthesis of a Primary (beta)-Azidoalcohol via Stereoselective Epoxidation of a Highly Functionalised di-o,o’-Substituted Styrene: Toward a New Total Synthesis of (-)-Quinocarcin

Diastereoselective epoxidation of a highly functionalised di-o,o’-substituted styrene combined with subsequent regioselective epoxide ring-opening afforded the corresponding primary (beta)-azidoalcohol, which is the required key intermediate for a new total synthesis approach toward (-)-quinocarcin and various unnatural D-ring modified analogues.