Title of article
Synthesis of 2,3-dihydro-1H-isoindole-1-thiones via the bromine–lithium exchange between 1-bromo-2-(1-isothiocyanatoalkyl)benzenes and butyllithium
Author/Authors
Kazuhiro Kobayashi، نويسنده , , Yuki Yokoi، نويسنده , , Tatsuya Nakahara، نويسنده , , Naoki Matsumoto، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
7
From page
10304
To page
10310
Abstract
The reaction of 1-bromo-2-(1-isothiocyanatoalkyl)benzenes, which are easily derived from 2-bromophenyl ketones or (2-bromophenyl)methanamine, with butyllithium generates 1-(1-isothiocyanatoalkyl)-2-lithiobenzenes, which immediately underwent intramolecular cyclization to give rise to the corresponding 3-substituted and 3,3-disubstituted 2,3-dihydro-1H-isoindole-1-thiones in good yields.
Keywords
2 , 3-Dihydro-1H-isoindole-1-thiones , Bromine–lithium exchange , Isothiocyanate , isocyanide , Butyllithium
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1106503
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