Title of article
Highly efficient and diastereoselective construction of bispirooxindoles through a cascade Michael-cyclization reaction
Author/Authors
Song Wu، نويسنده , , Xingli Zhu، نويسنده , , Wujun He، نويسنده , , Rongming Wang، نويسنده , , Xiaohua Xie، نويسنده , , Dabin Qin، نويسنده , , Linhai Jing، نويسنده , , Zeqin Chen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
8
From page
11084
To page
11091
Abstract
A series of bispirooxindole derivatives have been synthesized via a cascade Michael-Cyclization reaction between isothiocyanato oxindoles and methyleneindolinones with high yields (up to 98%) and excellent diastereoselectivities (up to >95:5 dr) under mild conditions. The structure and effect on the reaction of less studied 4-substituted methyleneindolinones have also been investigated.
Keywords
cascade reaction , Michael-cyclization reaction , Bispirooxindole , Methyleneindolinone , Isothiocyanato oxindole
Journal title
Tetrahedron
Serial Year
2013
Journal title
Tetrahedron
Record number
1106595
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