Title of article :
Catalytic asymmetric one-pot synthesis of α-methylene-γ-lactams
Author/Authors :
Xavier Company?، نويسنده , , Pierre-Yves Geant، نويسنده , , Andrea Mazzanti and Pietro Andreani ، نويسنده , , Albert Moyano، نويسنده , , Ramon Rios، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2014
Abstract :
An organocatalytic enantioselective synthesis of α-methylene-γ-lactams has been developed. The reaction between protected 2-aminomalonates and Morita–Baylis–Hillman carbonates is catalyzed by chiral Lewis bases to afford the corresponding lactams in excellent yields and moderate to good enantioselectivities, after work-up.
Keywords :
Organocatalysis , Lactams , Asymmetric synthesis , One-pot reaction , Morita–Baylis–Hillman
Journal title :
Tetrahedron
Journal title :
Tetrahedron
