Copper-catalyzed Csp3–O cross-coupling of unactivated alkyl halides with organic peroxides

An efficient Cu-catalyzed Csp3–O coupling of peroxides with haloalkanes is described. High yields of products were achieved under mild conditions. Significantly, in addition to primary alkyl halides, secondary alkyl halogenated hydrocarbons could also be applied to this system. The new reaction system could tolerate a wide range of organic peroxides.