Title of article :
A Convenient Synthesis of 4-Trifluoromethyl-(2H)-pyridazin-3-ones from Methyl 3,3,3-Trifluoropyruvate
Author/Authors :
Sibgatulin، Dmitriy A. نويسنده , , Volochnyuk، Dmitriy M. نويسنده , , Kostyuk، Alexandr N. نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A convenient two-step synthesis of 4-CF3-(2H)-pyridazin-3-ones starting from methyl 3,3,3-trifluoropyruvate (MeTFP) and carbonyl compounds has been elaborated. As a result, a set of various 4-CF3-(2H)-pyridazin-3-ones was obtained. The scope and limitations of the methodology is defined.
Keywords :
pyridazinones , aldol condensation , cyclocondensation , methyl 3,3,3-trifluoropyruvate , trifluoromethyl
