Title of article
New tetracyclic 1,4-oxazepines constructed via practically simple tandem condensation strategy from readily available synthons
Author/Authors
Alexander V. Sapegin، نويسنده , , Stanislav A. Kalinin، نويسنده , , Alexey V. Smirnov، نويسنده , , Mikhail V. Dorogov، نويسنده , , Mikhail Krasavin، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
7
From page
1077
To page
1083
Abstract
A streamlined synthetic methodology towards novel tetracyclic 1,4-oxazepines from readily available precursors is described. The compounds, designed as more soluble version of the earlier described, poorly soluble dibenzo[b,f][1,4]oxazepines, were obtained in high yields and as a single regioisomer as a result of three tandem chemical events—nucleophilic aromatic substitution, Smiles rearrangement and denitrocyclization.
Keywords
Smiles rearrangement , Oxazepines , Tetracyclic , Nucleophilic aromatic substitution , Solubilizing groups , Privileged structures , Bioisosteres , Denitrocyclization
Journal title
Tetrahedron
Serial Year
2014
Journal title
Tetrahedron
Record number
1106741
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