Title of article :
Convenient and Regioselective Synthesis of Nucleoside Phosphoramidate Monoesters
Author/Authors :
Fu، Hua نويسنده , , Zhao، Yufen نويسنده , , Zhu، Jigang نويسنده , , Jiang، Yuyang نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
We have developed a convenient and efficient method for the synthesis of nucleoside phosphoramidate monoesters. This step-wise synthesis, consisting of an ester exchange, reaction of the 5’-OH of nucleosides with fluorenylmethyl aryl phosphite, and an Atherton-Todd reaction, gave fluorenylmethyl nucleoside 5’-phosphoramidates; final removal of the fluorenylmethyl group yielded the desired target products in good yields.
Keywords :
nucleoside , phosphoramidate , ester-exchange , diphenyl phosphite , Atherton-Todd reaction
