Title of article
Enantio- and Diastereoselective Syntheses of Orthogonally Protected anti-2-Amino-1,3,4-butanetriols from an Achiral (beta)Ketoester
Author/Authors
Bourdreux، Yann نويسنده , , Drouillat، Bruno نويسنده , , Greck، Christine نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-2085
From page
2086
To page
0
Abstract
An efficient enantio- and diastereoselective synthesis of orthogonally protected anti-2-amino-1,3,4-butanetriols from an achiral source is described. The anti relationship between the two adjacent aminated and hydroxylated carbons was controlled by sequential hydrogenation of a (beta)-ketoester in the presence of a chiral ruthenium catalyst and electrophilic amination of the resulting (beta)-hydroxyester.
Keywords
aminobutanetriols , asymmetric synthesis , chiral ruthenium catalyst , orthogonal protecting groups , electrophilic amination
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110748
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