Title of article
The Synthesis of Arylketones via Friedel-Crafts Acyldegermylation
Author/Authors
Parr، Nigel J. نويسنده , , Spivey، Alan C. نويسنده , , Gripton، Christopher J. G. نويسنده , , Noban، Catherine نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-2166
From page
2167
To page
0
Abstract
Electron-rich and electron-neutral aryl trialkylgermanes are shown to be competent precursors to aryl ketones via FriedelCrafts acyldegermylation. Given the previously demonstrated greater stability towards basic/nucleophilic conditions of arylgermanes as compared to arylsilanes/stannanes, these reactions significantly expand the utility of group 14 acyldemetalation in synthesis. This is exemplified by the cleavage of Ge-based linker models for solid-phase synthesis (SPS).
Keywords
arylgermanes , solid-phase synthesis , electrophilic aromatic substitution , Friedel-Crafts acylation , oligothiophenes
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110788
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