Acid-Mediated Amine Exchange of N,N-Dimethylformamidines: Preparation of Electron-Rich Formamidines

The effect of acid in the amine exchange of N,N-dimethylformamidines has been revisited, allowing the preparation of highly electron-rich compounds that are difficult to obtain under standard conditions. The use of propargylamine as nucleophile led to the formation of substituted imidazoles.