Title of article :
Lewis Acid Mediated Reductive Ring Opening of 2-Methoxyethylidene Acetals: A New Approach to 2-Methoxyethyl (MOE) Ethers of cis-Diols
Author/Authors :
Hanessian، Stephen نويسنده , , Machaalani، Roger نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
The reductive opening of 2-methoxyethylidene acetals of vicinal diols in uridine and 1,4-anhydro-D-ribitol in the presence of TiCl4 and Et3SiH was investigated. The 3ʹ-O-(2-methoxyethyl) ether of uridine and the 2ʹ-O-(2-methoxyethyl) ether of 1,4-anhydro-D-ribitol were isolated and characterized. The results were rationalized based on coordination effects involving proximal substituents.
Keywords :
acetal , reductive opening , nucleoside , Antisense
