Title of article :
Solid-Support Synthesis of Natural Product-like Compounds Derived from D-(-)-Ribose
Author/Authors :
Marzinzik، Andreas L. نويسنده , , Messer، Roland نويسنده , , Pelle، Xavier نويسنده , , Lehmann، Hansjorg نويسنده , , Zimmermann، Jurg نويسنده , , Haner، Robert نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
The synthesis of natural product-like compounds on solid support is described. Starting from a readily accessible D-(-)ribose derivative, a tricyclic scaffold is prepared in five steps. After coupling onto solid supports bearing different substituents (PAL resins), the scaffold can be further derivatised at two diversity points. Representative derivatives obtained by this diversity-oriented procedure are described.
Keywords :
solid-phase synthesis , hetero Diels-Alder reactions , Furans , medicinal chemistry , combinatorial
