Title of article
Reversal of Enantioselectivity by Catalyst Protonation: Asymmetric Hydrocyanation of Imines with Oxazaborolidines
Author/Authors
Berkessel، Albrecht نويسنده , , Mukherjee، Santanu نويسنده , , Lex، Johann نويسنده ,
Pages
-40
From page
41
To page
0
Abstract
A new application of chiral oxazaborolidines in asymmetric transformation, namely the hydrocyanation of imines, is described. The effect of protonation of these catalysts on the reactivity and enantioselectivity of hydrocyanations is studied. Significant increase in reaction rate is observed upon protonation of the catalysts, along with the reversal of the sense of stereoinduction.
Keywords
oxazaborolidine , Asymmetric Catalysis , hydrocyanation , Imine , Protonation
Journal title
Astroparticle Physics
Record number
110880
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