Synthesis of ortho-Cyanopyridylboronic Acids and Esters toward Cyano-Functionalized Bipyridines

This work describes the synthesis of ortho-cyanopyridylboronic acids and esters. Their reactivity with pyridine halides in the Suzuki cross-coupling reaction is evaluated and shows that the cyanopyridyl boronic esters appear to be more stable than their corresponding acids. These esters allowed us to synthesize new ­cyanobipyridine systems.