Title of article
Highly Efficient One-Pot Synthesis of 1,2-Dihydro-2-oxo-3-pyridine-carboxylate Derivatives by FeCl3-Promoted [3+3] Annulation
Author/Authors
Tan، Anna Tan نويسنده , , Wang، Shaozhong نويسنده , , Li، Jianxin نويسنده , , Hu، Hongwen نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-2657
From page
2658
To page
0
Abstract
An efficient one-pot synthesis of 1,2-dihydro-2-oxo-3-pyridinecarboxylate derivatives starting from enones and ethyl cyanoacetate in moderate to good yields is described. This novel tandem [3+3] annulation method mediated by FeCl3 involves Michael addition and ketone-nitrile annulation followed by aromatization-dehydrogenation. A plausible mechanism is also proposed.
Keywords
ethyl cyanoacetate , 1,2-dihydro-2-oxo-3-pyridinecarboxylate , ferric chloride
Journal title
Synlett
Serial Year
2005
Journal title
Synlett
Record number
110887
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