Author/Authors :
Tamura، Yukio نويسنده , , Akiyama، Takahiko نويسنده , , Fuchibe، Kohei نويسنده , , Itoh، Junji نويسنده , , Morita، Hisashi نويسنده ,
Abstract :
Danishefsky’s diene and aldimine underwent aza Diels-Alder reaction under the influence of chiral phosphoric acid derived from (R)-BINOL as a chiral Br?nsted acid to afford piperidinone derivatives in good to high enantioselectivity. Addition of CH3CO2H improved both reactivity and enantioselectivity.
Keywords :
Danishefsky’s diene , asymmetric synthesis , chiral Br?nsted acid , aza-Diels-Alder reaction
