Title of article :
One-Pot Method for the Synthesis of Naphthyridines via Modified Friedl?nder Reaction
Author/Authors :
Zhichkin، Pavel نويسنده , , Beer، Catherine M. Cillo نويسنده , , Rennells، W. Martin نويسنده , , Fairfax، David J. نويسنده ,
Abstract :
A one-pot method for the preparation of 1,8-naphthyridine derivatives is reported. The method involves the dimetalation of an appropriate N-2-pyridylpivalamide or tert-butylcarbamate followed by reaction with a (beta)-dimethylamino or (beta)-alkoxyacrolein derivative. This method is also applicable to 1,6-naphthyridines.
Keywords :
pyridines , directed ortho-metalation , Cyclization , naphthyridines
Journal title :
Astroparticle Physics
