Title of article
Solid-Phase Synthesis and Cyclative Cleavage of Quorum Sensing Depsipeptide Analogues by Acylphenyldiazene Activation
Author/Authors
Janda، Kim D. نويسنده , , Shigenaga، Akira نويسنده , , Moss، Jason A. نويسنده , , Ashley، Fawn T. نويسنده , , Kaufmann، Gunnar F. نويسنده ,
Pages
-550
From page
551
To page
0
Abstract
Depsipeptide analogues of auto-inducing peptides (AIPs) from all four Staphylococcus aureus subgroups were prepared as panning reagents for in vitro antibody selection. Stepwise Fmoc solid-phase synthesis was used to prepare the linear precursors, which were cyclized without epimerization in a one-pot cleavage reaction following oxidation of the stable acylphenylhydrazine linkage to the reactive acylphenyldiazene.
Keywords
cyclic depsipeptide , AIP analogue , Cyclization , acyldiazene , quorum sensing
Journal title
Astroparticle Physics
Record number
110961
Link To Document