Title of article
Synthesis of (±)-1-Phenyl-2-azabicyclo[2.2.1]heptane Derivatives - Novel NK1 Receptor Ligands
Author/Authors
Raubo، Piotr نويسنده , , Kulagowski، Janusz J. نويسنده , , Chicchi، Gary G. نويسنده ,
Pages
-270
From page
271
To page
0
Abstract
The synthesis of the 1-phenyl-2-azabicyclo[2.2.1]heptane derivative 2, a potential NK1 receptor ligand, is reported. Ringclosing metathesis of diene 10 and regio- and stereoselective opening of the oxirane ring in 14 are key steps in the synthetic sequence.
Keywords
bicyclic compounds , ring-closing olefin metathesis , McMurry coupling , opening of epoxides , NK1 receptor
Journal title
Astroparticle Physics
Record number
111013
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