Title of article :
A Concise Synthesis of (S)-(gamma)-Fluoroleucine Ethyl Ester
Author/Authors :
Nadeau، Christian نويسنده , , Gosselin، Francis نويسنده , , O’Shea، Paul D. نويسنده , , Davies، Ian W. نويسنده , , Volante، Ralph P. نويسنده ,
Abstract :
We report herein a six-step, chromatography-free, through-process for the asymmetric synthesis of (S)-(gamma)-fluoroleucine ethyl ester sulfate salt (6) that proceeds in 25% overall yield from inexpensive ethyl glyoxylate. This approach features a Ti/Zncatalyzed glyoxylate-ene reaction-olefin hydrofluorination-amine alkylation as key steps.
Keywords :
enantioselective glyoxylate , olefin hydrofluorination , ene reaction , amine alkylation , asymmetric synthesis , (S)-(gamma)-fluoroleucine ethyl ester
Journal title :
Astroparticle Physics
