Author/Authors :
Imagawa، Hiroshi نويسنده , , Nishizawa، Mugio نويسنده , , Fujikawa، Yukari نويسنده , , Tsuchihiro، Atsushi نويسنده , , Kinoshita، Atsushi نويسنده , , Yoshinaga، Takayuki نويسنده , , Takao، Hiroko نويسنده ,
Abstract :
Hg(OTf)2·3TMU showed efficient catalytic activity for the cyclization of (omega)-alkynoic acid to give (omega)-methylene-(omega)-lactone in excellent yield, and the procedure was efficiently applied for the synthesis of naturally occurring (gamma)-methylene-(gamma)-lactone. The absolute structure of the natural product was established by this synthesis.
Keywords :
mercury , lactones , Carboxylic acids , catalytic cyclizations , Alkynes
