Title of article :
A Generic and Reproducible Route to Homo- and Heteroannular Bicyclic (beta)-Diketones via Knochel-Type 1,4-Conjugate Additions to (alpha),(beta)-Unsaturated Cycloalkenones
Author/Authors :
McGRATH، MATTHEW نويسنده , , Hill، Cheryl L. نويسنده , , Hunt، T. نويسنده , , Grogan، Gideon نويسنده ,
Abstract :
A generic and reproducible method for the preparation of homo- and heteroannular bicyclic (beta)-diketones is reported. The method employs the copper acetate mediated 1,4-conjugate addition of organozinc derivatives of iodopropionate and iodobutanoate esters to (alpha),(beta)-unsaturated cycloalkenones, followed by intramolecular Dieckmann condensation.
Keywords :
bicyclic compounds , cyclisations , enzymes , annulation , ketones
Journal title :
Astroparticle Physics
