Title of article :
An Efficient Asymmetric Synthesis of Cascarillic Acid
Author/Authors :
Bull، Steven D. نويسنده , , Cheeseman، Matt نويسنده ,
Abstract :
An efficient six-step asymmetric synthesis of the cyclopropane containing natural product cascarillic acid in 41% overall yield is described. The key synthetic steps involve the use of a temporary stereogenic hydroxyl group to control the facial selectivity of a directed cyclopropanation reaction and its subsequent removal via a retro-aldol reaction.
Keywords :
cascarillic acid , retro-aldol , temporary stereocentre , cyclopropane , aldol
Journal title :
Astroparticle Physics
