• Title of article

    A Short and Efficient Synthesis of Isoindolin-1-ones

  • Author/Authors

    Tsuritani، Takayuki نويسنده , , Kii، Satoshi نويسنده , , Akao، Atsushi نويسنده , , Sato، Kimihiko نويسنده , , Nonoyama، Nobuaki نويسنده , , Mase، Toshiaki نويسنده , , Yasuda، Nobuyoshi نويسنده ,

  • Pages
    -800
  • From page
    801
  • To page
    0
  • Abstract
    Here, we report a short and efficient synthesis of iso­indolin-1-ones. Base-induced cyclization of o-hydroxymethyl­benzamides, which was easily prepared from the corresponding phthalides and amines, led predominantly to N-alkylation in good yield. The reaction proceeded under mild conditions and bromine and nitrile substituents were tolerated. The selectivity is explained by HASB theory.
  • Keywords
    phosphate , N-selective alkylation , lactams , Cyclizations , lactones
  • Journal title
    Astroparticle Physics
  • Record number

    111096

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=111096