Author/Authors :
McDonald، Edward نويسنده , , Large، Jonathan M. نويسنده , , Clarke، Maria نويسنده , , Williamson، David M. نويسنده , , Collins، Ian نويسنده ,
Abstract :
An efficient, regioselective approach to the synthesis of trisubstituted pyrimidines was developed. Sequential functionalisation of commercially available polyhalopyrimidines provided the target compounds in moderate to good overall yields.
Keywords :
regioselectivity , Palladium , Pyrimidine , Suzuki , cross-coupling
