Author/Authors :
Teng، Hanbing نويسنده , , He، Yunjiao نويسنده , , Wu، Lamei نويسنده , , Su، Jiangtao نويسنده , , Feng، Xichun نويسنده , , Qiu، Guofu نويسنده , , Liang، Shucai نويسنده , , Hu، Xianming نويسنده ,
Abstract :
We report a new and facile synthetic approach to N(alpha)-Boc ureidoalanine derivatives from commercially available Boc-l-aspartic acid. Not only Nʹ-substituted but also Nʹ,Nʹ-disubstituted ureidoalanine derivatives may be obtained by this method. The key aspect of this method is the employment of a 5-oxazolidinone to provide proper protection of the (alpha)-nitrogen of l-aspartic acid. This ensures successful obtainment of the corresponding isocyanate by a Curtius rearrangement.
Keywords :
amino acids , ureidoalanine , protecting groups , Curtius rearrangement , 5-oxazolidinone
