Title of article :
Convenient and Efficient Synthesis of Pyrazole-Based DHODase Inhibitors from 3-Aryl-4-cyanosydnone
Author/Authors :
Wong، Fung Fuh نويسنده , , Yeh، Mou-Yung نويسنده , , Chang، En-Ming نويسنده , , Chen، Tse-Hsin نويسنده , , Chang، En-Chiuan نويسنده ,
Abstract :
Pyrazole-based DHODase inhibitors have been efficient and conveniently synthesized in 51-60% yield from 3-(p-aryl)-4-cyanosydnone via regioselective 1,3-diploar cycloaddition followed by an amidation and a Ritter reaction.
Keywords :
propargylic ester , DHODase inhibitors , Pyrazole , sydnones , 1,3-dipolar cycloaddition
Journal title :
Astroparticle Physics
