Title of article :
1-Trifluoromethyl-1-diethoxyphosphoryl Carbene: A New Synthon for the Preparation of CF3-Containing (alpha)-Hydroxy and (alpha)-Amino Phosphonic Acid Derivatives
Author/Authors :
Beletskaya، Irina P. نويسنده , , Titanyuk، Igor D. نويسنده , , Vorob’eva، Daria V. نويسنده , , Osipov، Sergej N. نويسنده ,
Abstract :
The first synthesis of diethyl 1-diazo-2,2,2-trifluoroethylphosphonate has been developed starting from readily available compounds. The synthetic utility of this compound is demonstrated via its Rh-catalyzed insertion into O-H and N-H bonds to produce CF3-substituted (alpha)-hydroxy phosphonic and (alpha)-amino phosphonic acid derivatives
Keywords :
hydroxyphoshonate , Insertion reactions , diazo compounds , Fluorine , aminophosphonates
Journal title :
Astroparticle Physics
