Title of article
A Facile Synthesis of an Oxazolo[5,4]pyrimidin-2-one and a Pyrimido[5,4][1,3]oxazin-2-one
Author/Authors
Niculescu-Duvaz، Dan نويسنده , , Springer، Caroline J. نويسنده , , Dijkstra، Harmen P. نويسنده , , Gaulon، Catherine نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
-1518
From page
1519
To page
0
Abstract
A facile synthesis is reported for the construction of the five- and six-membered fused carbamate rings of an oxazolo[5,4] pyrimidin-2-one and a pyrimido[5,4][1,3]oxazin-2-one, respectively. The method utilises a controlled two-step procedure in which a reactive p-nitrophenylcarbamate intermediate ring closes upon treatment with base, affording the bicyclic pyrimidinecarbamate scaffolds in good yields.
Keywords
pyrimidines , cyclic carbamates , heterocyclic chemistry , ring-closing
Journal title
Synlett
Serial Year
2006
Journal title
Synlett
Record number
111183
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