Title of article :
Concentration-Dependent Chemo- and Regioselective Metalation of 6,6-Dibromo-2,2-bipyridine
Author/Authors :
Motevalli، Majid نويسنده , , Watkinson، Michael نويسنده , , Ilyashenko، Gennadiy نويسنده , , Choudhury، Rahela نويسنده ,
Abstract :
A reliable and synthetically useful strategy for the selective single or double metalation of 6,6ʹ-dibromo-2,2ʹ-bipyridine via lithium-halogen exchange is discussed. Experimental conditions for the optimal formylation of the singly and doubly lithiated intermediates are outlined as well as unequivocal X-ray crystallographic evidence for the regiochemistry of a competing deprotonation pathway.
Keywords :
lithium-halogen exchange , bipyridine ligands , Metalation , regiocontrol
Journal title :
Astroparticle Physics
