Effects of noise on the off rate of Ca2+ binding proteins in a coupled biochemical cell system Original Research Article

We investigated numerically the kinetic properties of calcium binding proteins by using a three-calcium store model and discussed the response of a two-way coupled biochemical cell system, whose subsystems were coupled via diffusion-like cytosolic calcium transfer through gap junctions, to the external stimulation. When we used noise to modulate the off rate of the Ca2+ binding proteins in simulation, an SR-like phenomenon of synchronous oscillations is observed. In addition, the interaction involving noise, coupling and the dynamics of Ca2+ binding proteins is discussed.