Multifunctional gadofulleride nanoprobe for magnetic resonance imaging/fluorescent dual modality molecular imaging and free radical scavenging Original Research Article

Strategic design of gadofullerene derivatives is critical to integrate multifunctionality into one entity. Herein, an easy method was developed to fabricate a new type of magnetic resonance imaging/fluorescent integrative molecular imaging probe based on Gd@C82. The functionalized gadofulleride Gd@C82O∼14(OH)∼14(NH2)∼6 not only exhibits an order of magnitude larger relaxivity (47.0 ± 0.8 mM−1 s−1 at 0.5 T) than commercially used gadopentetic acid (4.5 ± 0.1 mM−1 s−1) under the same condition and multi-wavelength emission features derived from the multi-wavelength excitation for dual-modality diagnosis, but also highly efficient scavenging capability toward hydroxyl radicals.