Title of article :
CA3D: A Monte Carlo code to simulate 3D buffered diffusion of ions in sub-membrane domains Original Research Article
Author/Authors :
Amparo Gil، نويسنده , , Javier Segura، نويسنده ,
Issue Information :
دوهفته نامه با شماره پیاپی سال 2001
Pages :
25
From page :
269
To page :
293
Abstract :
CA3D is a simulation program, based on Monte Carlo techniques, which simulates the buffered diffusion of ions in the sub-membrane domain of cells. Two geometries of submembrane domains are considered. The first, a conical domain, applies to spherical cells with a locally uniform distribution of channels while the second, a cylindrical domain, is intended to model ciliar cells and presynaptic terminals. Other domains can be implemented in the code with ease. The entry of ions takes place through discrete entry points (channel pores). Ions diffuse inside the cell and react with endogenous or exogenous buffers, mobile or fixed. The diffusion of ions and binding molecules is modeled as a 3D random walk process by moving each individual ion and molecule. The reaction of ions with the binding molecules is also modeled probabilistically. The outputs of the code are concentration time courses and 2D maps of concentration of ions in the sub-membrane domain of cells.
Keywords :
Ion diffusion , Buffering , reaction-diffusion , Random walk
Journal title :
Computer Physics Communications
Serial Year :
2001
Journal title :
Computer Physics Communications
Record number :
1135593
Link To Document :
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