Hydrogenation of pyrrole derivatives I. Hydrogenations over palladium Original Research Article

The heterogeneous catalytic hydrogenation of 1-methyl-2-pyrrole ethanol resulted in 1-methyl-2-pyrrolidine ethanol, an important and valuable pharmaceutical intermediate. In non-acidic medium, with carbon supported palladium catalyst, applying solvent mixtures and mild reaction conditions (6 bar, 80°C) high conversion and selectivity were obtained. This hydrogenation is part of a newly developed and industrially feasible synthesis.