Hydrogenation of pyrrole derivatives Part III. Hydrogenation of methyl 1-methyl-2-pyrroleacetate Original Research Article

A new hydrogenation method for the saturation of the pyrrole ring has been applied in the hydrogenation of methyl 1-methyl-2-pyrroleacetate in non-acidic medium. Various catalytic metals and solvents have been screened. High conversion and selectivity were achieved with rhodium and ruthenium catalysts. In palladium catalyzed hydrogenations the selectivity was improved by appropriate solvents.