Author/Authors :
Tahbaz-lahafi، Behnoosh نويسنده Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Amirrassouli، Houshang نويسنده Proteomics Research Center, Faculty of Paramedical Sciences , , Namaki، Saeed نويسنده , , Kazerouni، Faranak نويسنده Department of Laboratory Medicine, Faculty of Paramedical Sciences, Shahid Beheshti University, MC, Tehran , , Akbari، Mohammad-Esmaeil نويسنده Cancer Research Center,Shohada Hospital , , Mohammadzade، Jahangir نويسنده Proteomics Research Center, Faculty of Paramedical Sciences , , Rahimipour، Ali نويسنده Proteomics Research Center, Faculty of Paramedical Sciences ,
Abstract :
GranzymeH is a functional cytotoxic serine protease of NK cell granules,which expands the cell death-inducing repertoire of innate immune system.The purpose of this study was to determine GranzymeH(GZMH)level in breast cancer(BC) and healty women.This study was performed on 30 patients with BC and 30 healty women.GZMH and Estrogen levels were measured in cancer patients and healty women subsequently using ELISA and Radioimmunoassay(RIA) methods. Mean GZMH value was lower in BC than healty women(p < 0.0001) and mean Estrogen level was higher in BC patients in comparison to healty women (p < 0.003).Our finding indicates probability of existance of suppressor or a problem in production of GZMH in cancer patients.
