Fiber-derived butyrate and the prevention of colon cancer
Author/Authors :
Christian A. Hassig، نويسنده , , Jeffrey K. Tong، نويسنده , , Stuart L. Schreiber، نويسنده ,
Issue Information :
ماهنامه با شماره پیاپی سال 1997
Pages :
7
From page :
783
To page :
789
Abstract :
Inhibition of the enzyme histone deacetylase by butyrate results in the direct transcriptional upregulation of the cyclin-dependent kinase inhibitor p21/Cip1/WAF1. We discuss a small-molecule-mediated signaling pathway to explain the suspected anti-colon-cancer properties of fiber-derived butyrate.
