Title of article
Small molecule-based laser inactivation of inositol 1,4,5-trisphosphate receptor Original Research Article
Author/Authors
Takanari Inoue، نويسنده , , Kazuya Kikuchi، نويسنده , , Kenzo Hirose، نويسنده , , Masamitsu Iino، نويسنده , , Tetsuo Nagano، نويسنده ,
Issue Information
ماهنامه با شماره پیاپی سال 2001
Pages
7
From page
9
To page
15
Abstract
Background: Chromophore-assisted laser inactivation (CALI) is a powerful method for the study of in situ protein function in cellular processes. By using CALI, it is possible to abrogate the function of a target protein with unprecedented spatial and temporal resolution. However, CALI has some limitations, which restrict wider biological application, owing mainly to the use of antibody for target recognition. To circumvent the limitations, we have developed small molecule-based CALI (smCALI).
Keywords
calcium release , 4 , 5-trisphosphate receptor , Small-molecular probe , Laser inactivation , inositol 1
Journal title
Chemistry and Biology
Serial Year
2001
Journal title
Chemistry and Biology
Record number
1158334
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