Title of article :
Profiling the specific reactivity of the proteome with non-directed activity-based probes Original Research Article
Author/Authors :
Gregory C. Adam، نويسنده , , Benjamin F. Cravatt، نويسنده , , Erik J. Sorensen، نويسنده ,
Issue Information :
ماهنامه با شماره پیاپی سال 2001
Abstract :
Background: The field of proteomics aims to characterize dynamics in protein function on a global level. However, several classes of proteins, in particular low abundance proteins, remain difficult to characterize using standard proteomics technologies. Recently, chemical strategies have emerged that profile classes of proteins based on activity rather than quantity, thereby greatly facilitating the analysis of low abundance constituents of the proteome.
Keywords :
Proteomics , Sulfonate , Activity-based , Aldehyde dehydrogenase , Probe
Journal title :
Chemistry and Biology
Journal title :
Chemistry and Biology