Author/Authors :
Christine Krauth، نويسنده , , Marta Fedoryshyn، نويسنده , , Christian Schleberger، نويسنده , , Andriy Luzhetskyy، نويسنده , , Andreas Bechthold، نويسنده ,
Abstract :
As glycosyltransferases found in nature often show distinct substrate specificity, glycosyltransferase engineering is an important research field. In this work, we were able to introduce an activity into a glycosyltransferase involved in natural product (landomycin E) biosynthesis. This was achieved by recognizing hot spot amino acids in glycosyltransferases which are strongly involved in determining substrate specificity.
