Ultrafiltration membrane reactors for enzymatic resolution of amino acids: design model and optimization

In this paper the possibility of continuous resolution of dl-phenylalanine, catalyzed by l-aminoacylase in a ultrafiltration membrane reactor (UFMR) is presented. A simple design model, based on previous kinetic studies, has been demonstrated to be capable of describing the behavior of the experimental system. The model has been used to determine the optimal experimental conditions to carry out the asymmetrical hydrolysis of N-acetyl-dl-phenylalanine.