Effect of Fe3O4, Fe and Cu doping on magnetic properties and behaviour in physiological solution of biological hydroxyapatite/glass composites

The effect of Fe, Fe3O4 and Cu additives on magnetic properties and behaviour in physiological solution of glass-reinforced biological hydroxyapatite composites has been investigated. 1 wt% of additive was admixed before the final sintering of composites at 500 or 780 °C. The relative green and sintered densities of the samples were analyzed for the influence of additives and sintering temperature on the composite properties. The morphology of composites exhibited a porous structure with a pore size of 0.1–200.0 μm for OK 015 and 0.2–600.0 μm for OK 6 samples. It has been found that the magnetic properties of the doped composites depend on their compositions, the nature of additive and sintering conditions. The influence of the additive phases on the degradation of the composites in physiological solution was studied in vitro. It has been shown that Fe3O4-doped OK 015, which has ferromagnetic properties, can be the most suitable material for targeted delivery of drugs.