Title of article
Enthalpy of solution of terfenadine in ethanol/water mixtures
Author/Authors
Jo?o Canotilho، نويسنده , , Felisbela S. Costa، نويسنده , , Adriano T Sousa، نويسنده , , J.Sim?es Redinha، نويسنده , , M.Lu??sa P Leit?o، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2000
Pages
5
From page
9
To page
13
Abstract
The enthalpy of solution of terfenadine in ethanol/water mixtures, 0–20.5 wt.% of water was determined by calorimetry. A Sudden increase of 1–2 kJ mol−1 in the enthalpy at a concentration value around 0.01 mol kg−1 is observed. This step in the enthalpy is interpreted as due to solute n-mer aggregates formation. The solubility of terfenadine in the cosolvent systems used in the calorimetric studies was determined.
Keywords
Terfenadine , Solute self-aggregation , Crystallization , Crystal design , Solubility , Polymorphism , Solution enthalpy
Journal title
Thermochimica Acta
Serial Year
2000
Journal title
Thermochimica Acta
Record number
1194522
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