Microcalorimetric study on the enhanced antitumor effects of 1-hexylcarbamoyl-5-fluorouracil by combination with hyperthermia on K-562 cell line

The antitumor effects of 1-hexylcarbamoyl-5-fluorouracil (Carmofur) combined with hyperthermia were studied on K-562 cell line by microcalorimetry and fluorescence microscopy. The effect was evaluated by the maximal thermal power of the cell line K-562 and the total energy Q released during the measurement period (44 h). The results indicate that the combination of Carmofur and hyperthermia has a synergetic effect. Hence, microcalorimetry is a powerful tool in fields of clinical cases and Carmofur is clinically useful in thermochemotherapy. The result of fluorescence microscope observations show that apoptosis occurs under the action of Carmofur combined with hyperthermia.